3CTN supports a portfolio of academic clinical trials that reflect the priorities of clinicians, researchers, patients, ministries of health and funders. Scientific oversight will be provided by the Portfolio Committee (PC) and management of the day-to-day operations is provided by the 3CTN Coordinating Centre. Academically sponsored trials that are included on the portfolio are eligible for 3CTN support.
3CTN aims to assist both clinicians/researchers and patients in finding cancer clinical trials that may be of benefit. Patients that are interested in participating in a clinical trial must contact their healthcare provider for details, but may wish to search the 3CTN Portfolio to know which trials are open to accrual at their local centre.
To view the 3CTN Portfolio Watch Newsletters for monthly trial updates, view the Portfolio Watch here.
Frequently Asked Questions
How do I know if a trial is eligible for the 3CTN Portfolio?
An eligible trial must meet the following criteria:
- Interventional oncology trial;
- Academically sponsored (Clinical Trial Applications held by academic institution);
- Open to multiple Canadian sites;
- Funded independently of 3CTN;
- Peer reviewed by external reviewers.
Should you have questions about trial eligibility please see the Trial Eligibility Criteria and Guidelines.
How do I submit a trial for consideration for the 3CTN Portfolio?
Complete this Portfolio Application Form and submit the completed form to info3ctn.ca
How are trials assessed for inclusion on the 3CTN Portfolio?
What do I do if the trial I submitted has not been Peer Reviewed?
The 3CTN Coordinating Centre can help facilitate peer review for an un-reviewed trial. Please see the documents listed below for further details:
|For Sites||For Reviewers|
|Process Guidelines||Reviewer Guidelines|
|Intake Form||Reviewer Form|
How do I know if my submitted trial application has been reviewed or approved?
If you have recently submitted a trial for review, please see the Portfolio Application Status Update Summary for a list of studies submitted to 3CTN for review and approval.
What happens once a trial is on the 3CTN Portfolio?
Once a trial has been assessed (as per the diagram above) and accepted on to the 3CTN Portfolio, a Network centre that has the opened the trial to accrual is eligible to receive per case funding (PCF) for those patients recruited above the centre’s established PCF trigger*
*as defined within individual contractual agreements between 3CTN and the Network centre site.
How much per case funding (PCF) will the site receive?
The PCF amount for 2018-2022 associated with each complexity rating is represented in the table below:
|Trial Complexity Score||PCF Amount ($)**|
|≥ 7 (High)||1000|
**PCF distribution is subject to available funding.
For questions or additional information, please refer to the 3CTN Portfolio Complexity Weighting Guidlines
How do you assess Portfolio Impact?
Adapted from published literature, 3CTN created categories to describe the mix of trials that make up the Network’s Portfolio. The customized framework developed with the Portfolio Committee’s input was derived from “The Importance of Doing Trials Right While Doing the Right Trial” paper (Dilts et. Al.) and can allow for analyses based on a standardized set of Study Criteria as well as defined Impact on Patient Population and Innovativeness (see below).
Results from periodic review will enable assessments of the different types of studies being undertaken at a given point, trends and changes over time as well as help articulate the overall impact of the Portfolio for funders and other stakeholders.
How do I view the results of 3CTN's Portfolio Impact Analysis?
To view an interactive report on the outcomes of 3CTN's Portfolio Impact Analysis, please click here.
Note: To access more information on trials you can right click the graphics in the report and go to drillthrough and click trials.
For more information or to provide feedback please contact info3ctn.ca.
How do I view Portfolio trials with publications?
To view a listing of Portfolio trials with publications, please click here.
Who do I contact for more information about the 3CTN Portfolio or the trial application process?
General enquires or submitting a new application: info3ctn.ca
Portfolio Administration questions: rebecca.xuoicr.on.ca
Facilitated Peer Review process or Trial Complexity Weighting System questions: info3ctn.ca